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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)

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Subcutaneous protocols achieve peak plasma levels within 24 hours and maintain therapeutic concentrations for 1216 hours, which supports once-daily dosing

This method puts vitamin B12 into the fatty tissue under the skin